Phenotypes Associated with This Genotype

Genotype
MGI:5607165

• Allelic Composition: Cd22^m2Btlr/Cd22^m2Btlr
• Genetic Background: C57BL/6J-Cd22^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:215821 )

• mice homozygous for this mutation exhibit an elevated frequency of B1a and B1b cells and a reduced frequency of B2 cells in the periphery.

• homozygous mutant mice exhibit reduced IgD mean fluorescence intensity.

abnormal CD4-positive, alpha-beta T cell physiology ( J:215821 )

• homozygous mutant mice exhibit a decreased frequency of effector memory CD4⁺ T cells along with an increased frequency of central memory CD4⁺ T cells.

immune system

abnormal B cell differentiation ( J:215821 )

• mice homozygous for this mutation exhibit an elevated frequency of B1a and B1b cells and a reduced frequency of B2 cells in the periphery.

• homozygous mutant mice exhibit reduced IgD mean fluorescence intensity.

abnormal CD4-positive, alpha-beta T cell physiology ( J:215821 )

• homozygous mutant mice exhibit a decreased frequency of effector memory CD4⁺ T cells along with an increased frequency of central memory CD4⁺ T cells.