Phenotypes Associated with This Genotype

Genotype
MGI:5606188

• Allelic Composition: Diaph1^tm1.1Sna/Diaph1^tm1.1Sna; Diaph2^tm1.2Sna/Diaph2^tm1.2Sna
• Genetic Background: B6N.Cg-Diaph1^tm1.1Sna Diahp2^tm1.2Sna

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:215740 )

♀N • layer formation in the somatosensory cortex is normal

abnormal neuronal migration ( J:215740 )

♀ • fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)

♀ • doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end

♀ • double cortin positive cells are disorganized on the lateral ventricle wall before migration

♀ • migration of cells out of explants cultured in Matrigel is reduced

♀ • migration of cells is slower

abnormal telencephalon morphology ( J:215740 )

♀

abnormal cerebral cortex morphology ( J:215740 )

♀ • fewer GABA cells in the cerebral cortex at E16.5

abnormal olfactory bulb morphology ( J:215740 )

♀

abnormal olfactory bulb granule cell layer morphology ( J:215740 )

♀ • marked loss of granule cells in adults

small olfactory bulb ( J:215740 )

♀ • reduced in size whereas brain size is normal

cellular

abnormal neuronal migration ( J:215740 )

♀ • fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)

♀ • doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end

♀ • double cortin positive cells are disorganized on the lateral ventricle wall before migration

♀ • migration of cells out of explants cultured in Matrigel is reduced

♀ • migration of cells is slower