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Phenotypes Associated with This Genotype
Genotype
MGI:5606171
Allelic
Composition		 Tg(TcraTcrb)425Cbn/0
Trim30atm1Yjk/Trim30atm1Yjk
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)425Cbn mutation (6 available)
Trim30atm1Yjk mutation (0 available); any Trim30a mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:215171 )
• T cells exhibit 10-20% enhanced proliferation compared to single Tg(TcraTcrb)425Cbn T cells, particularly when stimulated with a low dose of OVA(323-339) peptide

hematopoietic system
increased T cell proliferation ( J:215171 )
• T cells exhibit 10-20% enhanced proliferation compared to single Tg(TcraTcrb)425Cbn T cells, particularly when stimulated with a low dose of OVA(323-339) peptide

cellular
increased T cell proliferation ( J:215171 )
• T cells exhibit 10-20% enhanced proliferation compared to single Tg(TcraTcrb)425Cbn T cells, particularly when stimulated with a low dose of OVA(323-339) peptide

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory