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Phenotypes Associated with This Genotype
Genotype
MGI:5606049
Allelic
Composition
Ryr2tm1Krbr/Ryr2tm3.1Swch
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Ryr2tm1Krbr mutation (1 available); any Ryr2 mutation (330 available)
Ryr2tm3.1Swch mutation (0 available); any Ryr2 mutation (330 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die starting around 11 days post tamoxifen injection, with most dying by day 14

cardiovascular system
• 12 days post tamoxifen treatment, mice exhibit a reduced basal heart rate
• tamoxifen treated mice, however, do not exhibit stress-induced (by caffeine or epinephrine) ventricular tachyarrhythmias at young or older ages


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory