Phenotypes Associated with This Genotype

Genotype
MGI:5605720

• Allelic Composition: Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi}/Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}; Tg(Nes-cre/Esr1*)4Ynj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:206948 )

N • no change in the volume of the granule cell layer in the dentate gyrus or in the number of radial glia-like adult neural stem cells indicating no affect on the adult neural stem cell pool

abnormal dentate gyrus morphology ( J:206948 )

• increase in the number of NeuN+ neurons in tamoxifen treated mice at 3 weeks and 7 weeks of age

abnormal dendrite morphology ( J:206948 )

• average primary dendritic length and number of dendritic crossings are increased in the dentate gyrus in tamoxifen treated mice

abnormal dendritic spine morphology ( J:206948 )

• increase in spine density in the dentate gyrus in tamoxifen treated mice