Phenotypes Associated with This Genotype

Genotype
MGI:5605084

• Allelic Composition: Kl^kl/Kl^kl
• Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:214493 )

• mice show normal outer nuclear layer length and thickness, and no photoreceptor degeneration by 7 weeks of age, however retinal protein expression is altered

increased a-wave latency ( J:214493 )

• scotopic a-waves reach peak amplitude more slowly with increasing age

increased b-wave latency ( J:214493 )

• scotopic b-waves reach peak amplitude more slowly with increasing age

• however, photopic b-wave latency is unaffected

decreased a-wave amplitude ( J:214493 )

• scotopic, rod dominant ERG responses show that the maximum a-wave amplitude is reduced approximately 26% in 7 week old dark-adapted mice

decreased b-wave amplitude ( J:214493 )

• scotopic, rod dominant ERG responses show that the maximum b-wave amplitude is reduced approximately 38% in 7 week old dark-adapted mice

• photopic cone dominant ERG responses show that the b-wave amplitude is reduced by about 39% at 7 weeks of age