Analysis Tools
vision/eye
|
• from E17.5, fewer cells appear to undergo secondary fiber cell differentiation
• epithelial cells in lenses fail to undergo mitosis and exhibit DNA endoreduplication by E15.5-E17.5
|
|
• a reduced number of lens epithelial cells and the increase in nuclear size at E15.5-E17.5 suggest that cells bypass mitosis and undergo endoreduplication of their DNA during the cell cycle
|
|
• by E15.5, the nuclei in the differentiating secondary fibers at the bow region of lenses appears 152% larger compared to controls
• E17.5 lenses retain nuclei in the center of the lens, resulting in a failure to form an organelle-free zone
• fewer fiber cell nuclei are seen in various zones of the lens
|
