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Phenotypes Associated with This Genotype
Genotype
MGI:5604140
Allelic
Composition		 \Smad4tm2.1Cxd/\Smad4+
\Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm2.1Cxd mutation (2 available); any Smad4 mutation (46 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
malocclusion ( J:211171 )
• mice develop oral malocclusion

skeleton
malocclusion ( J:211171 )
• mice develop oral malocclusion
increased compact bone thickness ( J:211171 )
• cortical thickness is 23% higher

growth/size/body
malocclusion ( J:211171 )
• mice develop oral malocclusion

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory