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Phenotypes Associated with This Genotype
Genotype
MGI:5604136
Allelic
Composition		 Hand1tm3Abfi/Hand1+
Tg(Mpz-cre)94Imeg/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm3Abfi mutation (1 available); any Hand1 mutation (14 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
small frontal bone ( J:214092 )
• reduced size of frontal bones at E18.5, leading to a gap between the left and right frontal bones
small nasal bone ( J:214092 )
• reduced size of nasal bones at E18.5
abnormal nasal capsule morphology ( J:214092 )
• fusion of the nasal capsule is nearly complete at E18.5 although not phenotypically normal
abnormal palate development ( J:214092 )
• palate formation is improved compared to heterozygous Hand1tm3Abfi Tg(Wnt1-cre)2Sor mice

digestive/alimentary system
abnormal palate development ( J:214092 )
• palate formation is improved compared to heterozygous Hand1tm3Abfi Tg(Wnt1-cre)2Sor mice

growth/size/body
small nasal bone ( J:214092 )
• reduced size of nasal bones at E18.5
abnormal nasal capsule morphology ( J:214092 )
• fusion of the nasal capsule is nearly complete at E18.5 although not phenotypically normal
abnormal palate development ( J:214092 )
• palate formation is improved compared to heterozygous Hand1tm3Abfi Tg(Wnt1-cre)2Sor mice

respiratory system
small nasal bone ( J:214092 )
• reduced size of nasal bones at E18.5
abnormal nasal capsule morphology ( J:214092 )
• fusion of the nasal capsule is nearly complete at E18.5 although not phenotypically normal

skeleton
small frontal bone ( J:214092 )
• reduced size of frontal bones at E18.5, leading to a gap between the left and right frontal bones
small nasal bone ( J:214092 )
• reduced size of nasal bones at E18.5
abnormal nasal capsule morphology ( J:214092 )
• fusion of the nasal capsule is nearly complete at E18.5 although not phenotypically normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory