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Phenotypes Associated with This Genotype
Genotype
MGI:5603928
Allelic
Composition
Drd1tm2.1Stl/Drd1tm2.1Stl
Tg(Pomc-cre)1Lowl/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1tm2.1Stl mutation (1 available); any Drd1 mutation (72 available)
Tg(Pomc-cre)1Lowl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit deficits in contextual fear conditioning
• mice exhibit impaired fear memory in 24 hour contextual memory test at multiple time points as compared to control, however, mice exhibit normal cued fear conditioning during tone presentation and have a normal short term memory fear response
• mice exhibit similar fear response between two similar but different contexts, in contrast, controls freeze more in the original (shock) context than in the similar context


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory