Analysis Tools
behavior/neurological
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• mice exhibit deficits in contextual fear conditioning
• mice exhibit reduced freezing levels in 24 hour fear memory test, however, conditioning to tone is normal in an amygdala-dependent cued-fear conditioning protocol
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nervous system
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• impaired late phase long term potentiation (L-LTP) at the medial perforant path-dentate gyrus synapse
• mice exhibit a reduced fEPSP (excitatory postsynaptic potential) slope following a theta burst used to induce L-LTP as compared to controls
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