Phenotypes Associated with This Genotype

Genotype
MGI:5603321

• Allelic Composition: Lyn^M1Btlr/Lyn⁺
• Genetic Background: C57BL/6J-Lyn^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those of homozygous mutant and wild-type control mice

decreased B cell number ( J:214511 )

• B cell frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those in the blood of homozygous mutant and wild-type control mice

• proportions of peripheral blood IgM⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

• proportions of peripheral blood IgD⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

immune system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those of homozygous mutant and wild-type control mice

decreased B cell number ( J:214511 )

• B cell frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those in the blood of homozygous mutant and wild-type control mice

• proportions of peripheral blood IgM⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

• proportions of peripheral blood IgD⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice