Phenotypes Associated with This Genotype

Genotype
MGI:5603320

• Allelic Composition: Lyn^M1Btlr/Lyn^M1Btlr
• Genetic Background: C57BL/6J-Lyn^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice homozygous for this mutation are greater than in the blood of heterozyggous mutant or wild-type control mice

decreased B cell number ( J:214511 )

• B lymphocyte frequencies in the peripheral blood of mice homozygous for this mutation are lower than in the blood of heterozygous mutant or wild-type control mice

• proportions of IgM⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or wild-type mice.

• proportions of IgD⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or control mice.

immune system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice homozygous for this mutation are greater than in the blood of heterozyggous mutant or wild-type control mice

decreased B cell number ( J:214511 )

• B lymphocyte frequencies in the peripheral blood of mice homozygous for this mutation are lower than in the blood of heterozygous mutant or wild-type control mice

• proportions of IgM⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or wild-type mice.

• proportions of IgD⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or control mice.