Phenotypes Associated with This Genotype

Genotype
MGI:5588373

• Allelic Composition: Zc3h12d^tm1Tom/Zc3h12d^tm1Tom
• Genetic Background: B6.Cg-Zc3h12d^tm1Tom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:209383 )

N • mice exhibit normal steady-state lymphopoiesis

N • under Th17 cell-skewing conditions, cultured splenic CD4+ T cells exhibit normal differentiation

increased T cell proliferation ( J:209383 )

• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies

increased T-helper 17 cell number ( J:209383 )

• slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly increased during resolution phase in MOG-treated mice

increased interleukin-10 secretion ( J:209383 )

• from LPS-stimulated B cells

increased interleukin-6 secretion ( J:209383 )

• from LPS-stimulated B cells

increased susceptibility to experimental autoimmune encephalomyelitis ( J:209383 )

• MOG-treated mice exhibit high score and slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly higher proportion of Th17 cells in the CNS during the resolution phase compared with wild-type mice

• however, onset of paralysis and population of IFN-gamma-producing CD4+ Th1 cells are normal

hematopoietic system

increased T cell proliferation ( J:209383 )

• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies

increased T-helper 17 cell number ( J:209383 )

• slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly increased during resolution phase in MOG-treated mice

cellular

increased T cell proliferation ( J:209383 )

• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies