Phenotypes Associated with This Genotype

Genotype
MGI:5587926

• Allelic Composition: Gba1^tm1.1Eginn/Gba1^tm1.1Eginn
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:211953 )

• lower enzymatic activities in liver and spleen, 21% and 32%, respectively, compared to controls

nervous system

astrocytosis ( J:211953 )

• in striatum at 1 year of age

abnormal striatum morphology ( J:211953 )

• astrocytosis and alpha-synuclein accumulation in striatum at 1 year of age

alpha-synuclein inclusion body ( J:211953 )

• in striatum at 1 year of age

cellular

astrocytosis ( J:211953 )

• in striatum at 1 year of age