Phenotypes Associated with This Genotype

Genotype
MGI:5587829

• Allelic Composition: Snhg14^tm1Alb/Snhg14⁺; Ube3a^tm1Alb/Ube3a⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:207499 )

N • when the knock-out allele is inherited maternally, mice exhibit fully restored contextual conditioning behavior compared with mice heterozygous for the wild-type allele

abnormal emotion/affect behavior ( J:207499 )

• when the knock-out allele is inherited maternally, mice exhibit a slight improvement in performance in a marble burying test compared with mice heterozygous for the wild-type allele

impaired coordination ( J:207499 )

• on an accelerating rotarod in later trials when the knock-out allele is inherited maternally

• however, performance improved in the first few trials and in the hanging wire and dowel tests

decreased locomotor activity ( J:207499 )

• when the knock-out allele is inherited maternally, mice exhibit a trend towards improved activity levels compared with mice heterozygous for the wild-type allele

growth/size/body

growth/size/body region phenotype ( J:207499 )

N • when the knock-out allele is inherited maternally, mice exhibit normal body weight unlike in mice heterozygous for the wild-type allele

nervous system

nervous system phenotype ( J:207499 )

N • when the knock-out allele is inherited maternally, mice exhibit restored long term potentiation compared with mice heterozygous for the wild-type allele