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Phenotypes Associated with This Genotype
Genotype
MGI:5587825
Allelic
Composition		 \Hormad1tm1Kura/\Hormad1tm1Kura
\Spo11tm1Mjn/\Spo11tm1Mjn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1tm1Kura mutation (1 available); any Hormad1 mutation (31 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:213984 )
N
• oocyte cell death observed in Spo11 null mice is abrogated
abnormal female meiosis ( J:213984 )
• oocytes lack pseudo sex bodies
abnormal male meiosis ( J:213984 )
• spermatocytes from stage IV seminiferous tubules is reduced
• however, spermatocytes from stages I to III seminiferous tubules form pseudo sex bodies
abnormal male germ cell apoptosis ( J:213984 )
• apoptotic cells at the pachytene stage

cellular
abnormal female meiosis ( J:213984 )
• oocytes lack pseudo sex bodies
abnormal male meiosis ( J:213984 )
• spermatocytes from stage IV seminiferous tubules is reduced
• however, spermatocytes from stages I to III seminiferous tubules form pseudo sex bodies
abnormal male germ cell apoptosis ( J:213984 )
• apoptotic cells at the pachytene stage

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory