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Phenotypes Associated with This Genotype
Genotype
MGI:5586992
Allelic
Composition		 Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sor+
Tg(APPV717F)109Ili/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew mutation (0 available); any Gt(ROSA)26Sor mutation (1083 available)
Tg(APPV717F)109Ili mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system morphology ( J:213687 )
• mice show reduced concentrations of human amyloid beta40 and amyloid beta42 peptides in cortical and hippocampal extracts
• however, basal concentrations of brain interstitial fluid amyloid beta40 are unchanged in the brain parenchyma of adults compared to single Tg(APPV717F)109Ili mice
• concentrations of the soluble human APP alpha and APP beta are not affected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory