Phenotypes Associated with This Genotype

Genotype
MGI:5586725

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺; Tg(Agrp-cre)1Gsb/0
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:209418 )

N • mice exhibit normal body length

N • female and male mice fed a high fat high sugar diet exhibit normal body weight

increased body weight ( J:209418 )

♀ • female mice exhibit a tend toward increased body weight

decreased susceptibility to age related obesity ( J:209418 )

♂ • in male mice fed normal chow

behavior/neurological

behavior/neurological phenotype ( J:209418 )

N • mice fed normal chow or a high fat high sugar diet exhibit normal locomotor activity

decreased food intake ( J:209418 )

♂ • in male mice fed normal chow

increased food intake ( J:209418 )

♀ • in female mice fed normal chow

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209418 )

N • mice fed normal chow exhibit normal energy expenditure, plasma T4 levels, fasting-induced lipolysis and rectal temperature

N • mice fed a high fat high sugar diet exhibit normal energy expenditure and cold tolerance

increased response to leptin ( J:209418 )

• mice exhibit improved leptin sensitivity compared with control mice

adipose tissue

adipose tissue phenotype ( J:209418 )

N • mice fed normal chow or a high fat high sugar diet exhibit normal adiposity