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Phenotypes Associated with This Genotype
Genotype
MGI:5586504
Allelic
Composition		 Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+
Tg(Cebpb-tTA)5Bjd/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-Fosl2,-DsRed)Wag mutation (0 available); any Col1a1 mutation (166 available)
Tg(Cebpb-tTA)5Bjd mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased liver triglyceride level ( J:210545 )
• compared with control mice when fed a high fat diet
decreased susceptibility to diet-induced hepatic steatosis ( J:210545 )
• mice fed a high fat diet do not develop steatohepatitis unlike control mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:213764 )
N
• mice subjected to acetaminophen-induced hepatotoxicity exhibit a normal response
decreased liver triglyceride level ( J:210545 )
• compared with control mice when fed a high fat diet

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory