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Phenotypes Associated with This Genotype
Genotype
MGI:5586502
Allelic
Composition		 Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm3(tetO-Fosl1,-DsRed)Wag mutation (0 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (31 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver fibrosis ( J:213764 )
• periportal with immune infiltrate in doxycycline-treated mice

skeleton
abnormal skeleton morphology ( J:213764 )
• in doxycycline-treated mice at necropsy

growth/size/body
weight loss ( J:213764 )
• in doxycycline-treated mice
enlarged spleen ( J:213764 )
• in doxycycline-treated mice at necropsy

behavior/neurological
lethargy ( J:213764 )
• in doxycycline-treated mice

homeostasis/metabolism
ascites ( J:213764 )
• sometimes in doxycycline-treated mice at necropsy

hematopoietic system
enlarged spleen ( J:213764 )
• in doxycycline-treated mice at necropsy

immune system
enlarged spleen ( J:213764 )
• in doxycycline-treated mice at necropsy

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory