Phenotypes Associated with This Genotype

Genotype
MGI:5586500

• Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast physiology ( J:211215 )

• fewer mineralized nodules produced from primary osteoblasts under osteogenic conditions

abnormal osteoclast morphology ( J:211215 )

• increased osteoclast surface

decreased bone volume ( J:211215 )

abnormal osteoblast morphology ( J:211215 )

• decreased osteoblast surface

decreased bone trabecula number ( J:211215 )

decreased trabecular bone thickness ( J:211215 )

decreased bone ossification ( J:211215 )

• decreased bone formation

cellular

abnormal osteoblast physiology ( J:211215 )

• fewer mineralized nodules produced from primary osteoblasts under osteogenic conditions

homeostasis/metabolism

decreased circulating glucose level ( J:211215 )

• in mice fed a high fat diet

• however, levels are normal in mice fed a normal diet

decreased circulating osteocalcin level ( J:211215 )

impaired glucose tolerance ( J:211215 )

• in mice fed a normal diet and high fat diet

insulin resistance ( J:211215 )

• in mice fed a high fat diet

• however, mice fed a normal diet exhibit insulin tolerance

growth/size/body

increased body weight ( J:211215 )

• under normal diet and high fat diet

adipose tissue

adipose tissue phenotype ( J:211215 )

N • mice exhibit normal adipocyte number and size

increased gonadal fat pad weight ( J:211215 )

• under normal diet and high fat diet

hematopoietic system

abnormal osteoclast morphology ( J:211215 )

• increased osteoclast surface

immune system

abnormal osteoclast morphology ( J:211215 )

• increased osteoclast surface