Phenotypes Associated with This Genotype

Genotype
MGI:5586499

• Allelic Composition: Col1a1^{tm2(tetO-Fosl2,-DsRed)Wag}/Col1a1⁺; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal osteoblast physiology ( J:211215 )

skeleton

abnormal osteoblast physiology ( J:211215 )

abnormal osteoclast morphology ( J:211215 )

• decreased osteoclast surface

increased bone volume ( J:211215 )

abnormal osteoblast morphology ( J:211215 )

• increased osteoblast surface

increased bone trabecula number ( J:211215 )

increased trabecular bone thickness ( J:211215 )

increased bone ossification ( J:211215 )

• increased bone formation

homeostasis/metabolism

decreased insulin secretion ( J:211215 )

• in response to glucose stimulation

• in the pancreas

decreased circulating glucose level ( J:211215 )

• in mice fed a normal diet or a high fat diet

• however, infection with Adipoq-expressing adenovirus rescues serum glucose levels in mice fed a normal or high fat diet

decreased circulating insulin level ( J:211215 )

• in fasted mice fed a normal diet

• in mice fed a normal diet or a high fat diet

• however, bone insulin levels are normal and infection with Adipoq-expressing adenovirus rescues levels in mice fed a normal, but not high fat, diet

increased circulating osteocalcin level ( J:211215 )

improved glucose tolerance ( J:211215 )

• in mice fed a normal diet or high fat diet

• however, infection with Adipoq-expressing adenovirus restores glucose tolerance in mice fed a normal diet

increased insulin sensitivity ( J:211215 )

• in mice fed a normal diet or high fat diet

• however, infection with Adipoq-expressing adenovirus restores insulin sensitivity in mice fed a normal diet

decreased circulating adiponectin level ( J:211215 )

growth/size/body

decreased body weight ( J:211215 )

• under normal diet and high fat diet conditions

• however, infection with Adipoq-expressing adenovirus rescues body weight in mice fed a normal, but not high fat, diet

endocrine/exocrine glands

decreased insulin secretion ( J:211215 )

• in response to glucose stimulation

• in the pancreas

adipose tissue

adipose tissue phenotype ( J:211215 )

N • mice exhibit normal adipocyte number and size

decreased gonadal fat pad weight ( J:211215 )

• under normal diet and high fat diet conditions

• however, infection with Adipoq-expressing adenovirus rescues fat pad weight in mice fed a normal or high fat diet

hematopoietic system

abnormal osteoclast morphology ( J:211215 )

• decreased osteoclast surface

immune system

abnormal osteoclast morphology ( J:211215 )

• decreased osteoclast surface