Phenotypes for Kmt2d Myf5 MGI:5585627 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (171 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:207891 )

• mice die immediately after birth due to breathing malfunction

adipose tissue

decreased brown adipose tissue amount ( J:207891 )

abnormal brown fat cell differentiation ( J:207891 )

• moderate defects in brown adipose tissue differentiation in vitro

muscle

abnormal muscle morphology ( J:207891 )

decreased muscle weight ( J:207891 )

respiratory system

respiratory failure ( J:207891 )

• at birth

cellular

abnormal brown fat cell differentiation ( J:207891 )

• moderate defects in brown adipose tissue differentiation in vitro

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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