Phenotypes Associated with This Genotype

Genotype
MGI:5585596

• Allelic Composition: Tg(Chat-COP4*H134R/EYFP,Slc18a3)6Gfng/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:213335 )

induced hyperactivity ( J:213335 )

• following a first injection of low dose D-amphetamine mice spent less time in slow versus fast locomotion and exhibited an increase in distance travelled as compared to wild-type

increased stereotypic behavior ( J:213335 )

• 20 minutes after injection with high dose D-amphetamine transgenic mice exhibit severe and confined stereotypic behaviors such as floor/wall sniffing

nervous system

abnormal brain interneuron morphology ( J:213335 )

• increased number of cholinergic interneurons, however, compartmental distribution of processes is similar to control

abnormal striatum morphology ( J:213335 )

• cholinergic neuropil of the striatum is denser than neuropil found in controls