Phenotypes Associated with This Genotype

Genotype
MGI:5585303

• Allelic Composition: Ret^tm1Jmi/Ret⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

impaired branching involved in ureteric bud morphogenesis ( J:213514 )

• analysis of branching at 15.5 dpc revealed a subtle but significant (18%) decrease in ureteric branch tips in Ret+/- embryonic kidneys compared with littermate controls, although other metrics describing the structure of the branched tree were normal

• quantification of cap cells and tip cells per niche also trended toward larger cap and tip volumes (more like younger kidneys), although this did not reach statistical significance

• decreased niche number observed at P0 confirms the tip deficit observed at E15.5