Phenotypes Associated with This Genotype

Genotype
MGI:5585184

• Allelic Composition: Ago2^tm1.1Tara/Ago2^tm1.1Tara; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:210552 )

N • mice exhibit normal islet architecture, alpha cell number, total pancreas mass and beta cell cell death

N • mice fed a high fat diet exhibit normal islet morphometry

decreased pancreatic beta cell proliferation ( J:210552 )

abnormal pancreatic beta cell morphology ( J:210552 )

• increased beta cell size and total number of granules

• however, the number of docked granules is normal

decreased pancreatic beta cell mass ( J:210552 )

decreased pancreatic beta cell number ( J:210552 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:210552 )

N • mice fed a high fat diet exhibit normal glucose tolerance and energy expenditure

improved glucose tolerance ( J:210552 )

• at 10 weeks without altered insulin sensitivity

cellular

decreased pancreatic beta cell proliferation ( J:210552 )