Phenotypes Associated with This Genotype

Genotype
MGI:5584312

• Allelic Composition: Gja1^tm3.1Clo/Gja1^tm3.1Clo
• Genetic Background: B6.Cg-Gja1^tm1.1Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular smooth muscle cell proliferation ( J:212895 )

♂ • treatment of carotids with PDGF does not produce increases in vascular smooth muscle cell proliferation as seen in wild-type carotids

abnormal vascular wound healing ( J:212895 )

♂ • carotids from ligated mice shows reduced neointima formation compared to wild-type mice

cellular

abnormal vascular smooth muscle cell proliferation ( J:212895 )

♂ • treatment of carotids with PDGF does not produce increases in vascular smooth muscle cell proliferation as seen in wild-type carotids

homeostasis/metabolism

abnormal vascular wound healing ( J:212895 )

♂ • carotids from ligated mice shows reduced neointima formation compared to wild-type mice

muscle

abnormal vascular smooth muscle cell proliferation ( J:212895 )

♂ • treatment of carotids with PDGF does not produce increases in vascular smooth muscle cell proliferation as seen in wild-type carotids