Phenotypes for Pxdn MGI:5584292 MGI Mouse

eye inflammation ( J:213336 )

• congenital ocular inflammation, as determined by marker expression

abnormal optic nerve morphology ( J:213336 )

• disrupted nerve fiber and horizontal cell axons

optic nerve hypoplasia ( J:213336 )

• thin

abnormal anterior eye segment morphology ( J:213336 )

• delayed development at E17.5

• anterior segment dysgenesis at postnatal periods

abnormal iridocorneal angle ( J:213336 )

• at E15.5, the anterior and posterior chamber including the iridocorneal angle is filled with lens fiber cells

• the anterior chamber angle is filled with more lens fibers or mesenchymal cells

ciliary body hypoplasia ( J:213336 )

• ciliary body hypoplasia at P21

abnormal iris morphology ( J:213336 )

• forward-bending iris

• disorganized lens matrix at P21

iris hypoplasia ( J:213336 )

• at P21

decreased corneal epithelium thickness ( J:213336 )

• thinness at P21

abnormal corneal stroma morphology ( J:213336 )

• distortion of the parallel arrangement with more dense keratocytes distribution

• disorganized at P21

increased corneal stroma thickness ( J:213336 )

corneal opacity ( J:213336 )

corneal-lenticular stalk ( J:213336 )

• lens vesicle remains attached to the cornea by a persistent lens stalk in some mice

abnormal eye anterior chamber morphology ( J:213336 )

• progressive reduction in anterior chamber from E17.5 to adult

decreased eye anterior chamber depth ( J:213336 )

• very shallow or absent anterior chamber at P21 and in adult mice

absent eye anterior chamber ( J:213336 )

• very shallow or absent anterior chamber at P21 and in adult mice

abnormal eye posterior chamber morphology ( J:213336 )

• at E15.5, the anterior and posterior chamber including the iridocorneal angle is filled with lens fiber cells

ruptured lens capsule ( J:213336 )

• at E15.5 to E17.5 and at P21, mice exhibit loss of capsule structural integrity leading to extrusion of lens fiber cells into the anterior and posterior chambers

abnormal lens development ( J:213336 )

• defective lens fiber cell differentiation

fused cornea and lens ( J:213336 )

• at P21

abnormal lens epithelium morphology ( J:213336 )

• disorganized at P21

abnormal lens fiber morphology ( J:213336 )

• at E15.5, secondary lens fiber cells are reduced in number compared to in wild-type mice

• at P21, the number of secondary fibers in the transition zone is reduced compared to in wild-type mice

disorganized secondary lens fibers ( J:213336 )

• at E15.5 and P21

small lens ( J:213336 )

• at E15.5, at E17.5, P21 and in adult mice

microphthalmia ( J:213336 )

• at E17.5, P21 and in adult mice

• however, eye size is normal at E15.5

abnormal retina morphology ( J:213336 )

• retinal dysgenesis and retraction at P21

• early-onset glaucoma

decreased retina ganglion cell number ( J:213336 )

• at 3 weeks

abnormal retina inner limiting membrane morphology ( J:213336 )

• 9 of 28 mice exhibit loss of structural integrity of the inner limiting membrane

retina fold ( J:213336 )

• retinal folds and rosette-like structures are found in 88.9% mutants at P17-P21

• only local retinal folds and rosette-like structures are found in 32.1% mutants at E15.5-E17.5

retina gliosis ( J:213336 )

• in the inner plexiform layer

• in full retinal layers of some retinal regions

vitreous body deposition ( J:213336 )

• in 21 of 28 mice, mesenchymal cells aggregate and form the retrolental tissue in the vitreous

decreased cell proliferation ( J:213336 )

• at E15.5 in the anterior lens epithelium

• however, proliferation of epithelial cells in the transition zone is not severely affected

abnormal extracellular matrix morphology ( J:213336 )

• disrupted in the eyes with reduced cell adhesion

kinked tail ( J:213336 )

• however, further breeding disassociated the kinky tail from the small-eye phenotype

belly spot ( J:213336 )