Phenotypes for Cd22 Endou MGI:5582907 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd22^tm2Tft/Cd22^tm2Tft Endou^tm1Tft/Endou^tm1Tft
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm2Tft mutation (1 available); any Cd22 mutation (59 available)
Endou^tm1Tft mutation (0 available); any Endou mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:208364 )

N	• splenic B cell numbers are restored and reversed activation-induced B cell apoptosis with normal BCR-induced blast development and proliferation compared to in Cd22^tm2Tft homozygotes • the splenic B cell anergy phenotype observed in Cd22^tm2Tft homozygotes is rescued

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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