About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5582595
Allelic
Composition
Ryr2tm2Amks/Ryr2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm2Amks mutation (1 available); any Ryr2 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes
• however, a 1,4-benzothiazepine (Rycal S107) prevents calcium leak
• induced by atrial burst pacing in 7 of 10 mice
• however, a 1,4-benzothiazepine (Rycal S107) prevents atrial burst pacing-induced atrial fibrillation

muscle
• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes
• however, a 1,4-benzothiazepine (Rycal S107) prevents calcium leak
• leaky calcium channels in the sarcoplasmic reticulum of atrial and, to a lesser extent, ventricular myocytes
• however, a 1,4-benzothiazepine (Rycal S107) prevents calcium leak

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
catecholaminergic polymorphic ventricular tachycardia 1 DOID:0060675 OMIM:604772
J:212640


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory