Phenotypes Associated with This Genotype

Genotype
MGI:5582463

• Allelic Composition: Runx2^tm1Javed/Runx2^tm1Javed; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:212896 )

• mice die within a few minutes of birth due to respiratory failure

skeleton

abnormal craniofacial bone morphology ( J:212896 )

• some elements are undetectable or poorly developed

abnormal limb bone morphology ( J:212896 )

• short

absent metacarpal bones ( J:212896 )

abnormal metatarsal bone morphology ( J:212896 )

• absent

abnormal long bone epiphyseal plate morphology ( J:212896 )

• absent at E18.0 with a lack of hypertrophic chondrocytes and vasculature or blood cells in the mid-diaphyseal region of the femur

absent scapula ( J:212896 )

abnormal pelvic girdle bone morphology ( J:212896 )

• absent

short ribs ( J:212896 )

absent vertebrae ( J:212896 )

growth/size/body

decreased birth body size ( J:212896 )

decreased birth weight ( J:212896 )

respiratory system

respiratory failure ( J:212896 )

• in neonates

craniofacial

abnormal craniofacial bone morphology ( J:212896 )

• some elements are undetectable or poorly developed

limbs/digits/tail

abnormal limb bone morphology ( J:212896 )

• short

absent metacarpal bones ( J:212896 )

abnormal metatarsal bone morphology ( J:212896 )

• absent