Phenotypes for Erfe Hbb-b1 Hbb-b2 MGI:5582255 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Erfe^tm1Lex/Erfe^tm1Lex Hbb-b1^tm1Unc/Hbb-b1⁺ Hbb-b2^tm1Unc/Hbb-b2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erfe^tm1Lex mutation (2 available); any Erfe mutation (11 available)
Hbb-b1^tm1Unc mutation (2 available); any Hbb-b1 mutation (8 available)
Hbb-b2^tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211331 )

• mean corpuscular hemoglobin levels are decreased compared to double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

decreased mean corpuscular volume ( J:211331 )

• erythrocyte mean corpuscular volume is decreased compared to double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

homeostasis/metabolism

decreased circulating iron level ( J:211331 )

• serum iron concentrations are decreased compared to double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

abnormal hormone level ( J:211331 )

• increase in hepcidin levels

decreased liver iron level ( J:211331 )

• mice show less hepatic iron overload than double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

liver/biliary system

decreased liver iron level ( J:211331 )

• mice show less hepatic iron overload than double heterozygous Hbb-b1^tm1Unc and Hbb-b2^tm1Unc mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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