Phenotypes Associated with This Genotype

Genotype
MGI:5581951

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem; Pparg^{tm1.1(tTA)Jmgr}/Pparg⁺; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:178340 )

N • mice exhibit normal bone formation and osteoblast surface/numbers

decreased osteoclast cell number ( J:178340 )

abnormal osteoclast physiology ( J:178340 )

• decreased proliferation of osteoclast precursors

increased bone volume ( J:178340 )

• at 6 months

increased compact bone volume ( J:178340 )

• at 6 months

abnormal trabecular bone morphology ( J:178340 )

• more trabecular bone and bone surface at 6 months

increased trabecular bone volume ( J:178340 )

• at 6 months

increased bone trabecula number ( J:178340 )

• with reduced spacing at 6 months

increased trabecular bone thickness ( J:178340 )

• at 6 months

osteopetrosis ( J:178340 )

decreased bone resorption ( J:178340 )

hematopoietic system

extramedullary hematopoiesis ( J:178340 )

decreased osteoclast cell number ( J:178340 )

abnormal osteoclast physiology ( J:178340 )

• decreased proliferation of osteoclast precursors

immune system

decreased osteoclast cell number ( J:178340 )

abnormal osteoclast physiology ( J:178340 )

• decreased proliferation of osteoclast precursors