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Phenotypes Associated with This Genotype
Genotype
MGI:5581950
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (47 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (42 available)
Tg(tetO-cre)1Jaw mutation (7 available)
Tg(tetO-HIST1H2BJ/GFP)47Efu mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

hematopoietic system
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

cellular
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

immune system
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory