About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5581714
Allelic
Composition
Ncoa5tm1Hxia/Ncoa5+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa5tm1Hxia mutation (0 available); any Ncoa5 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice are fertile

homeostasis/metabolism
N
• mice exhibit normal serum insulin, triglyceride and free fatty acid levels
• at 6 weeks in male, but not female, mice
• increased circulating alpha-fetal protein at 6 and 12 months in male mice
• however, levels are normal at 2 months
• at 6 and 12 months in male mice
• early-onset at 6 weeks in male, but not female, mice
• at 6 weeks in male, but not female, mice
• in male, but not female, mice at 10 months
• however, levels at 6 month are normal

liver/biliary system
• chronic in male, but not female, mice with immune cell infiltrations around the bile ducts and in the portal areas, focal aggregates of lymphocytes, neutrophils and macrophage
• at 6 or 10 months, male mice exhibit dysplasia with disorganized architecture, cytological atypia, enlarged nuclei and vacuolated hepatocytes compare with wild-type and female mice
• in male, but not female, mice at 10 months
• however, levels at 6 month are normal
• in male, but not female, mice at 6 or 10 months
• in the periportal and periductular areas of male mice at 10 months
• at 10 to 18 months, nearly all male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice

neoplasm
• at 10 to 18 months, nearly all male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice

immune system
• chronic in male, but not female, mice with immune cell infiltrations around the bile ducts and in the portal areas, focal aggregates of lymphocytes, neutrophils and macrophage

cellular

endocrine/exocrine glands
• in male mice at 8 and 24 weeks
• decreased mass in male mice at 8 and 24 weeks


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory