Phenotypes Associated with This Genotype

Genotype
MGI:5581688

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Mafb,-tdTomato)Good}/Gt(ROSA)26Sor⁺; Tg(Neurog1-cre)1Jejo/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:207904 )

• most mice die at 3 weeks of age of unknown causes

nervous system

nervous system phenotype ( J:207904 )

N • cochlear wiring and in spiral ganglion neuron firing properties are normal

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• precocious basolateral localization of pre-synaptic ribbons in the hair cells

• however, the number of ribbons is normal

abnormal cochlear ganglion morphology ( J:207904 )

• afferent synapse development is accelerated in spiral ganglion neuron compared to in control mice

hearing/vestibular/ear

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• precocious basolateral localization of pre-synaptic ribbons in the hair cells

• however, the number of ribbons is normal