Phenotypes Associated with This Genotype

Genotype
MGI:5581687

• Allelic Composition: \Mafb^tm1.1Good/\Mafb^tm1Jeng; \Tg(Neurog1-cre)1Jejo/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:207904 )

N • mice survive through adulthood

nervous system

nervous system phenotype ( J:207904 )

N • spiral ganglion neuron (SGN) processes organization and density are normal

N • efferent innervation of cochlea is normal

N • SGN firing properties are normal

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• some are abnormally small or misshapen

• reduced numbers at P15

abnormal cochlear ganglion morphology ( J:207904 )

• failure of post-synpatic differentiation near the basolateral pole of the inner hair cells by P6

• impaired presynaptic development

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:207904 )

N • distortion product otoacoustic emissions are normal

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• some are abnormally small or misshapen

• reduced numbers at P15

increased or absent threshold for auditory brainstem response ( J:207904 )

• dampened auditory brainstem response (ABR) waveforms and elevated auditory thresholds

• ABR wave I is delayed with increased latency compared to in control mice