Phenotypes Associated with This Genotype

Genotype
MGI:5581471

• Allelic Composition: Myo1g^tm1.2Mfk/Myo1g^tm1.2Mfk
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired B cell migration ( J:209304 )

• in vivo, B cells exhibit slow migration and defective homing compared with wild-type cells

immune system

immune system phenotype ( J:209304 )

N • B cells exhibit normal activation and proliferation

N • mice exhibit normal spleen B cell subsets

decreased B cell number ( J:209304 )

• in lymph nodes and spleen

increased B cell number ( J:209304 )

• in peripheral blood

abnormal B cell physiology ( J:209304 )

• in vitro, B cell exhibit reduced anti-CD44- or anti-LFA-1-induced spreading with failure to develop long membrane projections and reduced adhesion compared with wild-type cells

• peritoneal B cells ingest more FITC-bacteria than wild-type cells

impaired B cell migration ( J:209304 )

• in vivo, B cells exhibit slow migration and defective homing compared with wild-type cells

decreased tumor necrosis factor secretion ( J:209304 )

• from cultured spleen cells

hematopoietic system

decreased B cell number ( J:209304 )

• in lymph nodes and spleen

increased B cell number ( J:209304 )

• in peripheral blood

abnormal B cell physiology ( J:209304 )

• in vitro, B cell exhibit reduced anti-CD44- or anti-LFA-1-induced spreading with failure to develop long membrane projections and reduced adhesion compared with wild-type cells

• peritoneal B cells ingest more FITC-bacteria than wild-type cells

impaired B cell migration ( J:209304 )

• in vivo, B cells exhibit slow migration and defective homing compared with wild-type cells