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Phenotypes Associated with This Genotype
Genotype
MGI:5581430
Allelic
Composition
Sorl1tm1Tew/Sorl1tm1Tew
Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1tm1Tew mutation (0 available); any Sorl1 mutation (131 available)
Tg(CMV-IgkvaD11)BCat mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 3 and 6 months of age, mice do not distinguish between old and new objects in the object recognition test
• at 12-14 months of age, however, the non-spatial memory deficit seen in the object recognition test disappears
• during the acquisition phase of the Morris water maze, 12 month old mutants do not learn as well as wild-type mice
• during the probe phase of the Morris water maze, 3, 6, and 12-14 month old mice are unable to remember the target quadrant

homeostasis/metabolism
• amyloid beta immunoreactive clusters in dystrophic neurites are seen to a similar extent in the hippocampus as in single Tg(CMV-IgkvaD11)BCat mice at 3 months of age, however by 6 months, the number of amyloid beta immunoreactive clusters is increased two-fold, but then is similar to single transgenics at 12-14 months of age, indicating acceleration of the amyloidogenic process

nervous system
• amyloid beta immunoreactive clusters in dystrophic neurites are seen to a similar extent in the hippocampus as in single Tg(CMV-IgkvaD11)BCat mice at 3 months of age, however by 6 months, the number of amyloid beta immunoreactive clusters is increased two-fold, but then is similar to single transgenics at 12-14 months of age, indicating acceleration of the amyloidogenic process
• phosphorylated tau is seen in neurons of the lateral entorhinal cortex, the neocortex and the hippocampus at 12-14 months of age, but not at earlier times; somatodendritic localization of phosphorylated tau is not observed
• mice show decreased numbers of ChAT-positive neurons only in the medial septum/diagonal band of Broca at 12-14 months of age
• normal numbers of ChAT-positive neurons are seen in the nucleus basalis of Meynert at 3, 6, and 12-14 months of age and in the medial septum/diagonal band of Broca at 3, and 6 months of age, indicating some protection from cholinergic neurodegeneration at early stages


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory