Phenotypes Associated with This Genotype

Genotype
MGI:5581428

• Allelic Composition: Sorl1^tm1Tew/Sorl1^tm1Tew
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:210074 )

• at 3, 6, and 12-14 months of age, mice do not distinguish between old and new objects in the object recognition test, exploring the new and familiar object equally

impaired spatial learning ( J:210074 )

• although mutants learn a well as wild-type mice during the acquisition phase of the Morris water maze, during the probe phase, 3, 6, and 12-16 month old mutants, are unable to remember the target quadrant

homeostasis/metabolism

amyloid beta deposits ( J:210074 )

• amyloid beta immunoreactive dystrophic neurites in the hippocampus are seen at 6 months and in the neocortex at 12 months

nervous system

amyloid beta deposits ( J:210074 )

• amyloid beta immunoreactive dystrophic neurites in the hippocampus are seen at 6 months and in the neocortex at 12 months

tau protein deposits ( J:210074 )

• phosphorylated tau is seen in neurons of the lateral entorhinal cortex, the neocrotex, and the hippocampus at 3, 6, and 12 months of age; somatodendritic localization of phosphorylated tau is not observed

abnormal cholinergic neuron morphology ( J:210074 )

• decrease in the number of ChAT-positive neurons in the nucleus basalis of Meynert at 6 and 12-14 months of age and in the medial septum/diagonal band of Broca at 3 and 6 months but not at 12-14 months

neuron degeneration ( J:210074 )

• degeneration of cholinergic neurons