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Phenotypes Associated with This Genotype
Genotype
MGI:5581427
Allelic
Composition		 Cdkn1btm1Mlf/Cdkn1b+
Tg(TG-TPR/NTRK1)#Rstn/0
Genetic
Background		 involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Tg(TG-TPR/NTRK1)#Rstn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased thyroid carcinoma incidence ( J:210015 )
• total number of papillary thyroid carcinomas that form is higher than in single Tg(TG-TPR/NTRK1)#Rstn transgenic mice
• however, a delay in onset of papillary thyroid carcinoma is seen compared to mice homozygous for Cdkn1btm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn mice

endocrine/exocrine glands
increased thyroid carcinoma incidence ( J:210015 )
• total number of papillary thyroid carcinomas that form is higher than in single Tg(TG-TPR/NTRK1)#Rstn transgenic mice
• however, a delay in onset of papillary thyroid carcinoma is seen compared to mice homozygous for Cdkn1btm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory