Phenotypes Associated with This Genotype

Genotype
MGI:5581426

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf; Tg(TG-TPR/NTRK1)#Rstn/0
• Genetic Background: involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased thyroid carcinoma incidence ( J:210015 )

• mice show a higher incidence of papillary thyroid carcinoma with a shorter latency period and increased proliferation index compared to single transgenic Tg(TG-TPR/NTRK1)#Rstn mice

• total number of papillary thyroid carcinomas is higher than in mice heterozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn

• tumor metastases to local cervical lymph nodes, peripheral lymph nodes or lungs are not seen

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:210015 )

• mice show a higher incidence of papillary thyroid carcinoma with a shorter latency period and increased proliferation index compared to single transgenic Tg(TG-TPR/NTRK1)#Rstn mice

• total number of papillary thyroid carcinomas is higher than in mice heterozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn

• tumor metastases to local cervical lymph nodes, peripheral lymph nodes or lungs are not seen