Phenotypes Associated with This Genotype

Genotype
MGI:5578120

• Allelic Composition: Tbc1d10c^tm1.2Psou/Tbc1d10c^tm1.2Psou
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:211913 )

N • mice exhibit normal B and T cell development and basal secretion of immunoglobulins

N • B cells do not exhibit spontaneous activation unlike T cells

N • ovalbumin-treated mice exhibit normal germinal center kinetics

N • mice treated with NP-LPS exhibit normal autoantibody production

abnormal B cell physiology ( J:211913 )

• accelerated antigen-specific B cell response in response to ovalbumin, NP-LPS and Borrelia burgdorferi infection

increased IgG level ( J:211913 )

• increased anti-ovalbumin IgG titer after ovalbumin treatment

• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice

abnormal T cell activation ( J:211913 )

• spontaneous activation

increased T cell proliferation ( J:211913 )

• after stimulation with anti-CD3 or anti-CD3/anti-CD28 antibodies

increased susceptibility to systemic lupus erythematosus ( J:211913 )

• CpG-DNA-treated mice exhibit increased anti-double stranded DNA antibody levels and renal IgG deposits compared with control mice

increased anti-double stranded DNA antibody level ( J:211913 )

• in CpG-DNA-treated mice

• however, untreated mice do not produce autoantibodies and do not when treated with anti-thyroglobulin or anti-actin antibodies

abnormal response to infection ( J:211913 )

• Borrelia burgdorferi-infected mice exhibit enhanced IgG response compared with wild-type mice

hematopoietic system

abnormal B cell physiology ( J:211913 )

• accelerated antigen-specific B cell response in response to ovalbumin, NP-LPS and Borrelia burgdorferi infection

increased IgG level ( J:211913 )

• increased anti-ovalbumin IgG titer after ovalbumin treatment

• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice

abnormal T cell activation ( J:211913 )

• spontaneous activation

increased T cell proliferation ( J:211913 )

• after stimulation with anti-CD3 or anti-CD3/anti-CD28 antibodies

cellular

increased T cell proliferation ( J:211913 )

• after stimulation with anti-CD3 or anti-CD3/anti-CD28 antibodies