Phenotypes Associated with This Genotype

Genotype
MGI:5576935

• Allelic Composition: Ryr2^tm1Krbr/Ryr2^tm1Krbr; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:210083 )

• tamoxifen-treated mice exhibit sudden cardiac death

cardiovascular system

decreased cardiac output ( J:210083 )

• in tamoxifen-treated mice

• however, compensatory mechanisms transiently ameliorate detrimental effects

abnormal sinus arrhythmia ( J:210083 )

• severe in tamoxifen-treated mice

decreased heart rate ( J:210083 )

• in tamoxifen-treated mice

sinus bradycardia ( J:210083 )

• in tamoxifen-treated mice

increased heart rate ( J:210083 )

• repetitive episodes of tachycardic arrhythmia in tamoxifen-treated mice

atrioventricular block ( J:210083 )

• secondary in tamoxifen-treated mice

abnormal T wave ( J:210083 )

• distinct T wave in tamoxifen-treated mice

cardiomyopathy ( J:210083 )

• in tamoxifen-treated mice

congestive heart failure ( J:210083 )

• in tamoxifen-treated mice

behavior/neurological

lethargy ( J:210083 )

• 4 days after tamoxifen treatment

homeostasis/metabolism

abnormal atrial thrombosis ( J:210083 )

• in tamoxifen-treated mice

muscle

cardiomyopathy ( J:210083 )

• in tamoxifen-treated mice