Phenotypes Associated with This Genotype

Genotype
MGI:5576914

• Allelic Composition: Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp; Tg(Myog-cre)1Eno/0
• Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:208380 )

• at 3 and 12 months in fasting mice

decreased circulating insulin level ( J:208380 )

• at 3 and 24 months

decreased respiratory quotient ( J:208380 )

• in the dark phase only

impaired glucose tolerance ( J:208380 )

• in aged mice

• however, glucose tolerance is normal at 3 and 12 months

insulin resistance ( J:208380 )

• in aged mice

• however, insulin resistance is normal at 6 months

growth/size/body

growth/size/body region phenotype ( J:208380 )

N • mice exhibit normal body weight

decreased lean body mass ( J:208380 )

• in aged mice

cellular

abnormal mitochondrial physiology ( J:208380 )

• decreased succinate dehydrogenase activity in the gastrocnemius of young and old mice

adipose tissue

increased percent body fat/body weight ( J:208380 )

• in aged mice