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Phenotypes Associated with This Genotype
Genotype
MGI:5576899
Allelic
Composition
Ppargc1atm1Brsp/Ppargc1atm2Brsp
Tg(Myog-cre)1Eno/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1atm1Brsp mutation (1 available); any Ppargc1a mutation (47 available)
Ppargc1atm2Brsp mutation (0 available); any Ppargc1a mutation (47 available)
Tg(Myog-cre)1Eno mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice fed standard chow or a high fat diet exhibit normal insulin tolerance
• hepatic glucose output under basal and clamped conditions is normal
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• mice exhibit increased systemic glucose uptake and glycolysis compared with control mice
• however, glycogen synthesis is normal
• in fed mice on standard chow
• however, fasted mice exhibit normal blood glucose levels
• in fasted and fed mice on a high fat diet
• in fed mice on standard chow or a high fat diet
• in fed mice on a high fat diet
• in mice fed a high fat diet

endocrine/exocrine glands
N
• islets exhibit normal basal and glucose-stimulated insulin secretion

growth/size/body
• in mice fed standard chow or a high fat diet
• in mice fed a high fat diet

immune system

adipose tissue
• in mice fed standard chow or a high fat diet

cellular
• decreased function as measured by Cox and succinate dehydrogenase activity

behavior/neurological
• during the day and night in mice fed a high fat diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory