Phenotypes Associated with This Genotype

Genotype
MGI:5576883

• Allelic Composition: Bmal1^tm2Bra/Bmal1^tm2Bra; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:162641 )

• 2-4 month old mice show decreased insulin secretion

• islets show diminished insulin responsiveness to glucose, KCL, exendin 4, forskolin and 8-bromo-cAMP, indicating a block in exocytosis

hyperglycemia ( J:162641 )

• 2-4 month old mice show increased ad libitum glucose levels throughout the day

impaired glucose tolerance ( J:162641 )

• 2-4 month old mice show impaired glucose tolerance

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:162641 )

• beta-cell function is defective at the very latest stage of stimulus-secretion coupling

decreased insulin secretion ( J:162641 )

• 2-4 month old mice show decreased insulin secretion

• islets show diminished insulin responsiveness to glucose, KCL, exendin 4, forskolin and 8-bromo-cAMP, indicating a block in exocytosis

behavior/neurological

behavior/neurological phenotype ( J:162641 )

N • mice show normal circadian activity, feeding rhythms and body weight

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diabetes mellitus		DOID:9351		J:162641