Phenotypes Associated with This Genotype

Genotype
MGI:5576879

• Allelic Composition: Tg(CAG-Ubqln1)2Hmw/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular sensitivity to oxidative stress ( J:206930 )

• increased tolerance of reactive oxygen species in liver at 2 months 6 hours post Menadione treatment

• decreased vacuolization, cell disruption, and karyolysis in liver sections at 2 months 6 hours post Menadione treatment

• decreased caspase-3 activity and neurodegeneration in brain cells and apoptotic cells in the cortex and the striatum at 2 months after 3 days of Menadione treatment

decreased hepatocyte apoptosis ( J:206930 )

• 6 hours post Menadione treatment

liver/biliary system

abnormal hepatocyte physiology ( J:206930 )

• increased tolerance of reactive oxygen species in liver at 2 months 6 hours post Menadione treatment

• decreased vacuolization, cell disruption, and karyolysis in liver sections at 2 months 6 hours post Menadione treatment

decreased hepatocyte apoptosis ( J:206930 )

• 6 hours post Menadione treatment

homeostasis/metabolism

abnormal response to CNS ischemic injury ( J:206930 )

• faster recovery of motor function following ischemic injury

decreased cerebral infarct size ( J:206930 )

• decreased ischemia/reperfusion-caused brain injury compared to wild-type

nervous system

abnormal response to CNS ischemic injury ( J:206930 )

• faster recovery of motor function following ischemic injury

decreased cerebral infarct size ( J:206930 )

• decreased ischemia/reperfusion-caused brain injury compared to wild-type