Phenotypes for Xbp1 MGI:5576525 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Xbp1^tm1.2Geno/Xbp1^tm1.2Geno
Genetic Background	involves: 129S2/SvPas * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xbp1^tm1.2Geno mutation (0 available); any Xbp1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die by E13.5

growth/size/body

embryonic growth retardation ( J:211440 )

decreased embryo weight ( J:211440 )

• at E12.5

cellular

decreased cell proliferation ( J:211440 )

• cultured E10.5 embryonic cells exhibit reduced cell proliferation and are not responsive to VEGF treatment unlike wild-type cells

integument

pallor ( J:211440 )

• in embryos

cardiovascular system

abnormal blood vessel morphology ( J:211440 )

• fewer blood vessels in embryos

embryo

embryonic growth retardation ( J:211440 )

decreased embryo weight ( J:211440 )

• at E12.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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